Epigenetic regulation of lineage commitment in normal and malignant hematopoiesis by histone demethylase KDM2B
نویسندگان
چکیده
Jaclyn Andricovich, Yan Kai, Weiqun Peng, Adlen Foudi, and Alexandros Tzatsos Cancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, and George Washington Cancer Center, George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA Department of Physics, George Washington University, Washington DC 20037, USA 4 INSERM UMR-S935, André Lwoff Institute, Paul Brousse Hospital, Villejuif, France
منابع مشابه
Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.
The development of the hematopoietic system is a dynamic process that is controlled by the interplay between transcriptional and epigenetic networks to determine cellular identity. These networks are critical for lineage specification and are frequently dysregulated in leukemias. Here, we identified histone demethylase KDM2B as a critical regulator of definitive hematopoiesis and lineage commit...
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Background: Epigenetic modifications are involved in different cellular processes through regulating chromatin dynamics. histone methylation is an important modification that can be dynamically regulated by histone methyltransferase and histone demethylase enzymes. JMJD1A (also known as JHDM2A and KDM3A) is a histone demethylase specific for H3K9me2/me1. JMJD1A is a key epigenetic regulator tha...
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